Post 10: Uncovered 2012 NIH Study Finds Carrot Juice Compound Falcarindiol Effective Against Cancer Cells in 9 of 10 Cancerous Strains Tested; Describes Mechanism
I just found (2/12/2016) a 2012 NIH (National Institute of Health) research study that showed that Falcarindiol, a chemical compound found abundantly in carrots, was able to cure 9 out of the 10 strains of cancer it was tested on without harming healthy cells. It also showed that this same compound increased the effectiveness of a chemotherapeutic drug. Specifically, the NIH-funded University of Chicago research team reported that the carrot ingredient Falcarindiol:
1) successfully killed the cells of 9 out of the 10 cancer cell strains that it was tested upon in vitro, in concentrations at or below 30% of a level that would be toxic to healthy cells, and
2) significantly increased the effectiveness of chemotherapy drug 5-fluorouracil.
The NIH study is titled:
"The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress"
Parts of the report are summarized below. For entire report go to:
An Excerpt from the Results section of the NIH report at the above link, followed by a key to tissue types:
"To determine whether FAD (Falcarindiol) can preferentially kill cancer cells, we compared the ability of FAD to induce cell death in HCT116 and SW480 human colorectal cancer cells with that in FHC normal human colon epithelial cells. As shown in [...], FAD kills both cancer cells in a dose-dependent manner and a low micromolar concentration of FAD is sufficient to induce significant levels of cell death in both cases. In contrast, FAD treatment does not induce a significant level of cell death in FHC normal human colon epithelial cells at 5–10 μM concentration [...]. In fact, the majority of FHC cells can survive 20 μM of FAD, even though a statistically significant level of cell death is observed at this concentration [...]. To further determine whether FAD can kill different types of cancer cells, we tested the effects of FAD on several cancer cells derived from different tissues (MDA-MB231, MCF7, DU145, MonoMac6, Raji, and KOPN-1) as well as non-transformed MCF10A and IEC6 cells. Although non-transformed cells are resistant to FAD treatment, most of the cancer cells, with the exception of MCF7, are sensitive to 6 μM of FAD [...]. These data indicate that FAD can preferentially kill cancer cells and that significant numbers of human cancers are sensitive to FAD."
Below is a key to the cancer tissue types tested
- HCT116: human colon carcinoma cells
- SW480: established from a primary adenocarcinoma of the colon
- MDA-MB231: human breast tissue
- MCF7: a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman
- DU-145: Together with PC3, considered a "classical" cell line of prostatic cancer
- MonoMac6: acute monocytic leukemia
- Raji: A line of lymphoblast-like cells established in 1963 from a Burkitt's lymphoma of a left maxilla
- KOPN-1: Childhood B acute lymphoblastic leukemia
- MCF10A: mammary gland; breast; "results [elsewhere] raise[d] a question as to whether the commonly used MCF10 cell line is a suitable model for human mammary cell studies"
- IEC6 cells: "an appropriate model of intestinal iron absorption in rats"
Also from the same NIH report:
"Falcarindiol (FAD) is a natural polyyne that has been shown to have anti-inflammation, antibacterial, and anticancer activities, as well as protective effects against hepatotoxicity. Moreover, these beneficial effects occur at non-toxic concentrations and thus represent pharmacologically useful properties. In this report, we show that FAD preferentially kills colorectal cancer cells and inhibits tumor growth, which is mediated by the induction of ER stress as a consequence of inhibiting proteasome function and causing accumulation of ubiquitinated proteins. Furthermore, FAD exhibits a strong synergistic effect in killing cancer cells in conjunction with 5-fluorouracil (5-FU), an approved chemotherapeutic drug for colorectal cancer. These results suggest that FAD can potentially be used to develop better and safer new therapies for colorectal cancers."
Comment:
Both Falcarindiol and Falcarinol, its nearly identical twin, another potent anti-cancer compound, are found in carrots in substantial amounts. They are also found in curled parsley leaf oil (which has them in 1.79% and 15% concentrations respectively according to one source), ginseng, and, according to Ann, parsnips. Ann also said that parsley seed oil is available online but that it is to be rubbed into the skin and should not be taken internally.
I will continue to primarily recommend carrot juice until somebody can convince me that they used the others to cure their cancer successfully and tell me how they did it. Carrot juice alone was what finally cured my cancer in 2006 and Ann Cameron's in 2013, and it has cured the cancer of many others that have contacted us. We know first hand how well carrot juice works and will be happy to teach you what we have learned, I through this website and Ann through her book, Curing Cancer With Carrots. If only the NIH or the surgeon general would do the same, we wouldn't have to.
So THERE'S THE PROOF! The NIH has known for years that carrot juice cures cancer, but just buried the information in their archive, (apparently) hoping we (the patients) wouldn't find out. But NOW WE HAVE. Get Juicing, World!
But let's also "raise a glass" to those NIH researchers that appear to have chosen to do the right thing. Hopefully, the politicians and the media will too, before long. But why wait for them? Share the link--- SPREAD THE WORD!!!
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